12 St. Paul Drive, Suite 105
Chambersburg, PA 17201
Mon-Fri: 8am-7pm, Sat: 8am-1pm

PH: 717.217.6790

TF: 855.217.6790

Low Dose Naltrexone (LDN)

Exploring the Uses of Low-Dose Naltrexone (LDN)

Naltrexone, an opiate receptor antagonist, is not a new drug, but when used off label at very low doses, is a drug shown in many trials to be of therapeutic benefit. The 50mg dose of Naltrexone was approved by the FDA in 1984 to treat opioid and alcohol addiction.

In 1985, Bernard Bihari, MD, a physician with a clinical practice in New York City, discovered the effects of a much smaller dose of Naltrexone. When reduced to doses ranging from 0.5mg to 9.0mg daily, it can modulate the immune system and may provide relief to those suffering from autoimmune diseases, chronic pain, mental health challenges, and inflammation.

Over the past ten years, there has been a growing body of evidence that the body’s endorphins (naturally occurring opioids) have a crucial role in regulating the immune system and providing pain relief. LDN’s blockade of opioid receptors has been shown to upregulate endorphin production. LDN’s blockade of Toll Like Receptors is believed to contribute to the anti-inflammatory and immune dampening effects.

These mechanisms help us understand why LDN can be beneficial for so many patients. LDN continues to provide life changing outcomes for many patients. It is available only by prescription and custom made at a compounding pharmacy.

The key to success in using LDN is an understanding that optimal dosing is ultimately patient specific and is not dependent on a set protocol. Dosing strategies can vary tremendously. Some patients find success very quickly, while others need to try a variety of dosing strategies, which may take up to several months to achieve success. Therefore, it is critical to work with a provider or a compounding pharmacy knowledgeable in strategies that can help ensure success with LDN.

Since we began specializing in LDN at Norland Avenue Pharmacy, we have seen a wide variety of successes. It is these successes that motivate us to continue to try to help other patients.

NOTE: Because LDN is an opioid receptor blocker, caution should be taken when prescribing LDN to patients who are taking opioid-type pain medications such as Morphine, Oxycodone, Hydrocodone, and Fentanyl.

Patient Testimonials

"Before I felt bad all the time. I was sick a lot, and I didn't want to get out of bed. Now, I might have an occasional flare-up, but it's mostly under control." 

"I've done a complete 180. I recouped all my functions. It helps my sleep. My constitution is much stronger, and my immune system is much stronger."

"LDN is amazing! Before I started taking LDN my TSH level was 4.5. After three months on LDN, my TSH level was 0.8."

"LDN's helped with sleep and definitely helped with flare-ups. I'm afraid to go off of it!"

"I've noticed a pretty significant difference. My thyroid function has improved. My joint pain has improved. I definitely would recommend LDN to others."

"I was taking nine gabapentin pills a day for nerve pain in my feet. I stopped taking gabapentin four months ago. I would recommend LDN, and I wouldn't go off of it."

"I experienced a reduction in muscle pain and in stiffness in my fingers and toes."

"I used to have burning pain in my hips. I took a lot of pain and nerve medications. LDN has provided relief. I'm doing a lot better, and I don't take any other meds now."

"After starting LDN I definitely have better sleep and less pain. I used to get up through the night in pain. Now I don't!"

"I noticed a huge difference after starting LDN. I was taking 500mg of gabapentin a day. Now I'm completely off of it."

"I had been taking a double dose of Remicade for a year, 80mg per day of prednisone, and wellbutrin. I was able to wean off of all of them. I am no longer anemic. My depression, anxiety, and insomnia all resolved. I've been in remission for six years."

  • ALS (Lou Gehrig's Disease)
  • Addiction
  • Addison's Disease
  • Alopecia Areata
  • Alzheimer's Disease
  • Amyotrophic Lateral Sclerosis
  • Ankylosing Spondylitis
  • Anxiety
  • Atopic Allergy
  • Atopic Dermatitis
  • Autism Spectrum Disorders
  • Behcet's Disease
  • Benign Prostatic Hypertrophy (BPH)
  • Brain Fog
  • COPD
  • CREST Syndrome
  • Celiac Disease
  • Chronic Fatigue Syndrome
  • Complex Regional Pain Syndrome
  • Crohn's Disease
  • Depression
  • Dermatomyositis
  • Diabetes Mellitus Type I
  • Eczema
  • Ehlers-Danlos Syndrome
  • Endometriosis
  • Fibromyalgia
  • General Anxiety Disorder
  • Granulomatosis
  • Graves’ Disease
  • HIV/AIDS
  • Hailey-Hailey Disease
  • Hashimoto’s Disease
  • Hypothyroidism
  • Irritable Bowel Syndrome (IBS)
  • Kawasaki’s Disease
  • Lupus
  • Lyme Disease
  • Meniere’s Disease
  • Migraine Headaches
  • Multiple Sclerosis (MS)
  • Obsessive Compulsive Disorder (OCD)
  • Pandas Disease
  • Parkinson’s Disease
  • Pemphigoid
  • Periodontal Disease
  • Polycystic Ovary Syndrome (PCOS)
  • Post-Traumatic Stress Disorder (PTSD)
  • Primary Lateral Sclerosis (PLS)
  • Psoriasis
  • Psoriatic Arthritis
  • Restless Leg Syndrome
  • Rheumatoid Arthritis
  • SIBO
  • Sarcoidosis
  • Scleroderma
  • Sjogren’s Syndrome
  • Stiff Person Syndrome (SPS)
  • Transverse Myelitis
  • Ulcerative Colitis
  • Wegener’s
  • Weight Loss
  • Women’s Health
  • Vitiligo

…for Multiple Sclerosis

Cree et al: Naltrexone and QOL in MS Annals of Neurology. February 2010(1)1-18 | UC-San Francisco Medical School https://www.ncbi.nlm.nih.gov/pubmed/20695007


…for Depression

Mischoulon et al: For Patients with Breakthrough Depression of Major Depressive Disorder (MDD) on Antidepressants. Journal of Affective Disorders 208. (2017) 6-14 | Harvard Medical School https://www.jaacap.org/article/S0165-0327(16)30449-9/abstract


…for Fibromyalgia

Younger et al: Fibromyalgia Symptoms are Reduced by Low-Dose Naltrexone: A Pilot Study. Pain Medicine 2009 (10):663-72 | Stanford Medical School https://www.ncbi.nlm.nih.gov/pubmed/19453963


…for Crohn’s Disease

Smith et al: Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease Pilot Study. Am J Gastroenterol 2007; 102:820-828 | Penn State Medical School https://www.ncbi.nlm.nih.gov/pubmed/17222320


…for Inflammation and Pain

Younger et al: The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain. Clinical Rheumatology (2014) 33:451-459 | Stanford Medical School https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/

Refer to LDNresearchtrust.org for more information

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